ENTRY       EC 1.14.11.16
NAME        Peptide-aspartate beta-dioxygenase
            Aspartate beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    Peptide L-aspartate + 2-Oxoglutarate + O2 =
            Peptide 3-hydroxy-L-aspartate + Succinate + CO2
SUBSTRATE   Peptide L-aspartate
            2-Oxoglutarate
            O2
PRODUCT     Peptide 3-hydroxy-L-aspartate
            Succinate
            CO2
COFACTOR    Iron
COMMENT     Requires Fe2+. Some vitamin K-dependent coagulation factors, as
            well as synthetic peptides based on the structure of the first
            epidermal growth factor domain of human coagulation factor IX or
            X, can act as acceptors.
GENES       HSA: ASPH
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.11.16
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.16
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