ENTRY       EC 1.13.11.5
NAME        Homogentisate 1,2-dioxygenase
            Homogentisicase
            Homogentisate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    Homogentisate + O2 = 4-Maleylacetoacetate
SUBSTRATE   Homogentisate
            O2
PRODUCT     4-Maleylacetoacetate
COFACTOR    Iron
COMMENT     Requires Fe2+.  Formerly EC 1.13.1.5 and 1.99.2.5.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 203500  Homogentisate 1,2-dioxygenase (homogentisate oxidase);
                         Alkaptonuria (3)
GENES       HSA: HGD(HGO)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.5
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.5
///