ENTRY       EC 1.13.11.42
NAME        Indoleamine-pyrrole 2,3-dioxygenase
            Indoleamine 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Indoleamine:oxygen 2,3-dioxygenase (indole-decyclizing)
REACTION    L-Tryptophan + O2 = N-Formylkynurenine
SUBSTRATE   L-Tryptophan
            O2
            Indoleamine
            Melatonin
PRODUCT     N-Formylkynurenine
COMMENT     Acts on many substituted and unsubstituted indoleamines, including
            melatonin. Involved in the degradation of melatonin.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 147435  Indoleamine 2,3-dioxygenase
MOTIF       PS: PS00876  G-G-S-[AN]-[GA]-Q-S-S-x(2)-Q
            PS: PS00877  [FY]-L-[DQ]-[DE]-[LIVM]-x(2)-Y-M-x(3)-H-[KR]
GENES       SYN: sll1541
            HSA: INDO(IDO)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.42
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.42
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