ENTRY       EC 1.13.11.34
NAME        Arachidonate 5-lipoxygenase
            Leukotriene-A4 synthase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 5-oxidoreductase
REACTION    Arachidonate + O2 =
            (6Z,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate;
            Arachidonate + O2 =
            5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (6Z,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
            (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
            Leukotriene A4
INHIBITOR   Caffeic acid
            AA861
            2-Heptyl-4-hydroxyquinoline-N-oxide
COMMENT     The product shown above is further converted by the enzyme into
            (7Z,9E,11Z,14Z)-(5S,6S)-5,6-epoxyeicosa-7,9,11,14-tetraenoate
            (leukotriene A4).
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
MOTIF       PS: PS00081  [LIVMA]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NQR]-[GST]-H-[LIVMSTAC](3)-E
GENES       HSA: ALOX5(Hs.89499)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.34
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.34
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