ENTRY EC 1.13.11.33
NAME Arachidonate 15-lipoxygenase
CLASS Oxidoreductases
Acting on single donors with incorporation of molecular oxygen
(oxygenases)
With incorporation of two atoms of oxygen
SYSNAME Arachidonate:oxygen 15-oxidoreductase
REACTION Arachidonate + O2 =
(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
SUBSTRATE Arachidonate
O2
PRODUCT (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
COMMENT The product is rapidly reduced to the corresponding 15S-hydroxy
compound.
PATHWAY PATH: MAP00590 Prostaglandin and leukotriene metabolism
MOTIF PS: PS00081 [LIVMA]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
PS: PS00711 H-[EQ]-x(3)-H-x-[LM]-[NQR]-[GST]-H-[LIVMSTAC](3)-E
GENES HSA: ALOX15(Hs.73809)
DBLINKS University of Geneva ENZYME DATA BANK: 1.13.11.33
WIT (What Is There) Metabolic Reconstruction: 1.13.11.33
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