ENTRY       EC 1.13.11.31
NAME        Arachidonate 12-lipoxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 12-oxidoreductase
REACTION    Arachidonate + O2 =
            (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
INHIBITOR   3-Methoxytropolone
COMMENT     The product is rapidly reduced to the corresponding 12S-hydroxy
            compound.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DISEASE     MIM: 152391  Arachidonate 12-lipoxygenase
MOTIF       PS: PS00081  [LIVMA]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NQR]-[GST]-H-[LIVMSTAC](3)-E
GENES       HSA: ALOX12(Hs.1200)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.31
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.31
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