ENTRY EC 1.13.11.30
NAME Stizolobinate synthase
CLASS Oxidoreductases
Acting on single donors with incorporation of molecular oxygen
(oxygenases)
With incorporation of two atoms of oxygen
SYSNAME 3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase
$ (recyclizing)
REACTION 3,4-Dihydroxy-L-phenylalanine + O2 =
5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
SUBSTRATE 3,4-Dihydroxy-L-phenylalanine
O2
PRODUCT 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
COFACTOR Zinc
COMMENT The intermediate product undergoes ring closure and oxidation,
with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme
requires Zn2+.
PATHWAY PATH: MAP00350 Tyrosine metabolism
DBLINKS University of Geneva ENZYME DATA BANK: 1.13.11.30
WIT (What Is There) Metabolic Reconstruction: 1.13.11.30
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