ENTRY       EC 1.13.11.29
NAME        Stizolobate synthase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase
            $ (recyclizing)
REACTION    3,4-Dihydroxy-L-phenylalanine + O2 =
            4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
SUBSTRATE   3,4-Dihydroxy-L-phenylalanine
            O2
PRODUCT     4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
COFACTOR    Zinc
COMMENT     The intermediate product undergoes ring closure and oxidation,
            with NAD(P)+ as acceptor, to stizolobic acid. The enzyme requires
            Zn2+.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.29
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.29
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