ENTRY       EC 1.13.11.27
NAME        4-Hydroxyphenylpyruvate dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,
            decarboxylating)
REACTION    3-(4-Hydroxyphenyl)pyruvate + O2 = Homogentisate + CO2
SUBSTRATE   3-(4-Hydroxyphenyl)pyruvate
            O2
PRODUCT     Homogentisate
            CO2
COMMENT     The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the
            enzymes from other sources may contain essential iron or copper.
            Formerly EC 1.14.2.2 and 1.99.1.14.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DISEASE     MIM: 276710  4-hydroxyphenylpyruvate dioxygenase; Tyrosinemia, type
                         III (1)
GENES       HSA: HPD(PPD)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.27
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.27
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