ENTRY       EC 1.13.11.17
NAME        Indole 2,3-dioxygenase
            Indole oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Indole:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    Indole + O2 = 2-Formylaminobenzaldehyde
SUBSTRATE   Indole
            O2
PRODUCT     2-Formylaminobenzaldehyde
            Anthranilate
COFACTOR    Flavin
            Copper
COMMENT     The enzyme from Jasminum is a flavoprotein containing copper, and
            forms anthranilate as the final product. One enzyme from Tecoma
            stans is also a flavoprotein containing copper and uses 3 atoms of
             oxygen per molecule of indole, to form anthranil
            (3,4-benzoisoxazol). A second enzyme from Tecoma stans, which is
            not a flavoprotein, uses 4 atoms of oxygen and forms anthranilate
            as the final product.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       HSA: IDO(Hs.840)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.17
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.17
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