ENTRY       EC 1.13.11.11
NAME        Tryptophan 2,3-dioxygenase
            Tryptophan pyrrolase
            Tryptophanase
            Tryptophan oxygenase
            Tryptamine 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    L-Tryptophan + O2 = L-Formylkynurenine
SUBSTRATE   L-Tryptophan
            O2
            Tryptamine
            D-Tryptophan
            5-Hydroxytryptophan
            Serotonin
PRODUCT     L-Formylkynurenine
COFACTOR    Protoheme
COMMENT     A protohemoprotein. Broad specificity towards tryptamine and
            derivatives including D- and L-tryptophan, 5-hydroxytryptophan
            and serotonin.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 191070  Tryptophan oxygenase
GENES       HSA: TDO2
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.11.11
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.11
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