ENTRY EC 1.1.3.35
NAME Salutaridine synthase
(R)-Reticuline oxidase (C-O phenol-coupling)
CLASS Oxidoreductases
Acting on the CH-OH group of donors
With oxygen as acceptor
REACTION (R)-Reticuline + NADPH + O2 = Salutaridine + NADP+ + 2 H2O
SUBSTRATE (R)-Reticuline
NADPH
O2
PRODUCT Salutaridine
NADP+
H2O
COMMENT Forms the Merphinan alkaloid Salutaridine by intramolecular phenol
oxidation of Reticuline without the incorpotation of oxygen into the
product.
DBLINKS University of Geneva ENZYME DATA BANK: 1.1.3.35
WIT (What Is There) Metabolic Reconstruction: 1.1.3.35
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