XVI International Botanical Congess

The model of a-tubulin three-dimensional structure is first offered. The models of a-tubulin molecules was developed aside both for normal biotype of goosegrass (Eleusine indica [L.] Gaertn.) and for mutant biotype, which is steady to both dinitroaniline and phosphoroamide herbicides due to change of THR to ILE at 239 position. Spatial changes which grew due to abovementioned mutation were analysed as well. It was determined that mutation leads to great changes in tubulin globule structure, in particular to the change in the character of secondary structure not only close to the place of mutation but in a great many of distant parts of molecule. The original method is offered which allow us to trace the places of possible binding of tubulin with low-molecular compounds on the base of steric accordance. It is determined that sensibility/steadiness to herbicide depends upon the three-dimensional structure of plant a-tubulin.