ibclogo XVI International Botanical Congess


Abstract Number: 5132
Poster No. = 2308


CHEMICAL CONSTITUENTS OF PIERIS FORMOSA (ERICACEAE)


Guo-wei Qin, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China


Pieris formosa (Wall)D.Don (Ericaceae) is an evergreen shrub or tree, growing mainly in hilly and valley regions of south and southwest China. It's a well-known poisonous plant as recorded in many Chinese medical monographs. It has been described that the poultry would fall into coma after taking leaves or stems of the plant accidentally. Various symptoms including dyspnea, motion imbalance and spreading the four limbs would appear if mice were administrated with its chloroform extracts. In folk medicine, the juice of fresh leaves can be used as insecticide and as a lotion for treatment of tinea and scabies. In the course of our study we found that EtOAc and BuOH fractions of the ethanol extracts were active in brine shrimp lethality test, which encouraged us to undertake a chemical investigation of the plant. This paper describe the isolation and structure elucidation of nineteen diterpenoids (1-19)of the plant,among which ten are new grayanane or leucothane diterpenoids named pierisformosins B,C and D, and pierisformosides A,B,C,D,E,F and G. Preliminary results of bioactivity screening of isolated compounds will be discussed.


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