XVI International Botanical Congess
Abstract Number: 2802
Session = Little is known about association and separation of homologous chromosomes during meiosis I, partly due to the absence of mutants that display stabilized homologue association. Here we report the isolation and characterization of such an Arabidopsis mutant. In the mutant the homologues remain associated following metaphase I, and one pair of them appears to be associated at, or in proximity to, the rDNA genes. The disrupted gene is highly homologous to the human and yeast SKP1 genes. The function of yeast Skp1p includes targeting specific proteins for degradation by the ubiquitin-mediated proteolysis. Thus, the Arabidopsis gene might control homologue separation by degrading a protein involved in regulation of homologue separation.
THE ARABIDOPSIS SKP1-LIKE1 GENE IS
ESSENTIAL FOR HOMOLOGOUS CHROMOSOME SEPARATION.
M. Yang*, Y. Hu*, M. Lodhi#, W. R. McCombie#, H. Ma* (*Dept of Biology, Penn State University, University Park, PA 16802, USA, #Cold Spring Harbor Lab., Cold Spring Harbor, NY 11724, USA)
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