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Module 6: NORTH AMERICAN MEDICINAL PLANTS

(Texts: Duke, 1986; Moerman, 1986)



OUTLINE

A. American Herbs with European a/o Asian Success Stories

1. Bayberry (Myrica cerifera)

2. Bearberry (Uva Ursi) (Arctostaphylos uva-ursi)

3. Bilberry (Vaccinium myrtillus)

4. Black Cohosh (Cimicifuga racemosa)

5. Black Walnut (Juglans nigra)

6. Bloodroot (Sanguinaria canadensis)

7. Cascara sagrada (Rhamnus purshianus)

8. Coneflower (Echinacea spp.)

9. Cranberry (Vaccinium macrocarpum)

10. Evening Primrose (Oenothera biennis)

11. Ginseng (Panax quinquefolius)

12. Goldenseal (Hydrastis canadensis)

13. Mayapple (Podophyllum peltatum)

14. Passionflower (Passiflora incarnata)

15. Saw Palmetto (Serenoa repens)

16. Skullcap (Scutellaria sp.)

17. Slippery Elm (Ulmus fulva)

18. St. John's-wort (Hyperericum punctatum)

19. White Pine (Pinus strobus)

20. White Oak (Quercus alba)

21. Wild Cherry (Prunus serotina)

22. Wild Yam (Dioscorea villosa)

23. Witchhazel (Hamamelis occidentalis)

24. Yew (Taxus spp.)

B. More localized (or introduced and weedy) here in America

1. Birchbark (Betula lenta)

2. California Poppy (Eschscholtzia californica)

3. Eyebright (Euphrasia sp.)

4. Horsebalm (Monarda punctata)

5. Horsetail (Equisetum arvense)

6. Ladyslipper (Cypriperdium sp.)

7. Licorice (Glycyrrhiza echinata)

8. Lobelia (Lobelia inflata)

9. Pennyroyal (American) (Hedeoma pulegiodes)

10. Pilewort (Collinsonia canadensis)

11. Pokeweed (Phytolacca americana)

12. Sassafras (Sassafras albidum)

13. Willow (American species) (Salix sp.)

14. Wintergreen (Gaultheria procumbens)

1. Burdock (Arctium lappa) (?Introduced Weed)

2. Chickweed (Stellaria media) (Introduced weed)

3. Dandelion (Taraxacum officinale) (Introduced weed)

4. Dock (Rumex obtusifolia) (?Introduced Weed)

5. Honeysuckle (Lonicera japonica) (Introduced weed)

6. Kudzu (Pueraria lobata) (Introduced weed)

7. Red Clover (Trifolium pratense) (Introduced weed)

8. Sheep Sorrel (Rumex acetosella) (?Introduced Weed)

9. Stinging Nettle (Urtica dioica) (Introduced weed)

10. Valerian (Valeriana officinalis) (Introduced weed)

REFERENCES: Duke's Handbook of Northeastern Indian Medicinal Plants (1986); Moerman's Medicinal Plants of Native America (1986)

THE TOP TEN

(GREEN IS GOOD)

1. Echinacea sp. Coneflower 9.9% 158,400,000

2. Allium sativum Garlic 9.8 156,800,000

3. Hydrastis canadensis Goldenseal 7.0 112,000,000

4. Panax spp. Ginseng 5.9 94,000,000

5. Ginkgo biloba Ginkgo 4.5 72,000,000

6. Serenoa repens Saw Palmetto 4.4 70,400,000

7. Aloe Aloe vera 4.3 68,800,000

8. Ephedra sp. Ma Huang 3.5 56,000,000

9. Eleutherococcus senticosus Siberian ginseng 3.1 49,600,000

10.Vaccinium spp. Cranberry 3.0 48,000,000

Echinacea's tops with you,

Can prevent the cold and flu;

N'you can run the flu away

With some garlic pills today.

It's sure that you can really heal

With a touch of goldenseal,

While the real ginseng is really cool;

Puts some power in your tool.

(Drink some ginseng with your lunch

Put some power in your punch)

If your memries fadin' way

Ginkgo pills will help it stay

You can keep your prostate well

With a saw palmetto pill

From the Bible you can learn;

'Bout Aloe, good for burns

China's known it all along,

'bout the magic of ma huang.

You can eliminate some stress

With eleuthero's caress

(Siberian ginseng, yes

Helps relieve you of your stress)

Urinary germs cut loose

With cranberries' healthy juice

QUAKER'S DOZEN

Keep depression on the run

With the magic of Saint John

Escape the sour grapes of wrath

On the evening primrose path.



I wonder what's to be

What will come of you and me

We can't just pop a pill

We depend on chlorophyll.

Take a moment if you will

And give thanks to chlorophyll

Think about it, you'll recall

That it's green that feeds us all

The plants you will recall

Make the food that feeds us all

And the medicines they give

Help the Herbal Village live

Not to mention all the flowers

Help bring smiles to all our hours

And there's more to all those blooms;

They are loaded with perfumes.

Yes the flower in its grace

Puts a smile on frowning face

And I think that we all should

Think about it if we would

GREEN is GOOD

Ladyslipper's scarce

And the goldenseal is rare

And the ginseng just ain't there

Beware

AMERINDIAN MEDICINAL PLANTS

The Indian branches of my family tree

Lay long concealed, moot mystery;

But my mother lately confided in me

My great aunt Exra was Cherokee!

Uncle Roland married quietly

Another Indian decorating my tree,

But the Cherokee side of my family tree

Leads elsewhere but not to me,

The trail of tears, but a memory;

Adopted into the family tree;

So I'm as caucasian as I can be,

And don't even think like the Cherokee

I thought was part of me (1986)

All that was written a decade ago

But now there's news you need to know

Irony has struck the family tree

My son John married Cherokee

His John, Kara and Sara make three

Cherokee's back in the family tree (1996)

(First published in Duke's Handbook of Northeastern Indian Medicinal Plants, Quarterman Publications, 1986. Now only available, like several of Duke's books, from the American Botanical Council, P.O. Box 201660. Austin, TX 78720-1660)

I've seen published estimates of the Amerindian arrival on this continent ranging from 12,000 to 100,000 years ago. Virtually all non-headline hunting anthropologists will side with the shorter time span. I'll be generous and speculate that AmerIndians have had some 20 millennia to evolve an empirical relationship with the native American plants. Many of those "virtually all" anthropologists will speculate that man (Homo, sensu lato), not necessarily Chinese man has been in current China and probably also Java and India for at least a million years. Does that mean that the Ayurvedic, Chinese (TCM) and Jamu (Indonesian) traditional medicines are better because mankind (Homos, sensu lato) has coevolved with plantkind there for 1,000,000 years (1000 millennia). And that African Homo, for more than 2,000,000 years (2,000 millennia), has had even more time to coevolve with the African flora and fauna.

Traditional Med Coevolution Millennia Generations

(Years)

EUROAMERICAN 500 0.5 25

AMERINDIAN ~20,000 20 1,000

AYURVEDIC ~1,000,000 1,000 50,000

CHINESE ~1,000,000 1,000 50,000

JAMU ~1,000,000 1,000 50,000

AFRICAN ~2,000,000 2,000 100,000

Coevolution of Man with Traditional Medicine Systems

If we accept the very broad rounded numbers I have tabulated, then we see that the Asian traditions have coevolved with man for 50 times longer than the Amerindian, while in Africa, the cradle of mankind, man has coexisted and coevolved with the African Flora 100 times longer than the Amerindian has coevolved with the American Flora and Fauna, natural foods and medicines. Yet Eurocaucasians like myself are using more Amerindian medicinal plants than African medicinal plants.

Recent press suggests strongly the power or religion in medicine. While the Bible and Koran did not stress medicinal plants as much as faith in healing, both are full of references to medicinal plants. At the cross roads of the African and Eurasian world, the Holy Land Bridge marks the most likely "exodus" route for wander lusting early man leaving the African continent for the first time, to radiate out in various directions. The geographical crossroads was also an ecological crossroads, where rainforest and desert Africans funneled in to meet Mediterranean Africans. And evolved Africans and Caucasians would meet again and again in this narrows we call the Holy Land.

This leads to a deeper appreciation of early Arabic, Biblical, Coptic, and Moslem medicinal wisdom, which has roots several orders of magnitude earlier than our adventurous AmerIndians who crossed a colder, more cruel land bridge, another meeting of continents and life epochs. And the emigrating->immigrating bridge crossing first Americans brought with them genetic and mental recollections of many of the Russo/Sino/Tibetan foods and medicines, many of which have cognates here in North America. Perhaps some of the eurosiberian weeds, bitter herbs of the Bible, traveled with them, intentionally in their survival (food and medicine) kits or hitchhiking as homophilic weedy waifs, long associated with non-agricultural humans near human dwellings.

Perhaps the healthiest recommendation in the Bible is to "eat with bitter herbs", anticipating by a couple millennia the NIH appeal to eat your leafy veggies. The bitter herbs of the Bible have variously been interpreted to include chicory, dandelion, endive, lettuce, sheep sorrel, and watercress. Zohary (1982) adds dwarf chicory and poppy-leaved Reichardia, and by close juxtaposition, rocket. I find it more bitter than the endive, lettuce, and watercress. All of these bitter herbs contain many important nutraceuticals which primitive and modern agriculture tends to select against as seeds of more palatable variants are saved, more bitter ones discarded; or modern agriculture selectively breeds to diminish the bitter nutraceuticals. I suspect that a half cup a day each of five of these bitter herbs would lower the incidence of many diseases of modern man.

But the AmerIndians, like Caucasian Americans, have adopted many of these bitter herbs into their pharmacopoeia. Alphabetically first is the chicory, which the Cherokee and Houma used as a tonic for the nerves. Iroquois used the root as a wash and poultice for chancres and fever sores. This may even foreshadow the great antiviral news for chicory and its namesake cichoric acid. This news suggests that cichoric acid, perhaps in many of our bitter herbs, especially in dandelion and chicory, and the Amerindian coneflower, may have antiHIV activity.

Perhaps none of the Biblical bitter herbs are native to America, but all are represented among our weeds. Alphabetically second, dandelion, if alien, has nonetheless entered the pharmacopoeia, of the Aleuts, the Bella Coola, Cherokee, Chippewa, Delaware, Fox, Iroquois, Kiowa, Mohegan, Ojibwa, Papago, Potawatomi, Rappahannock, and Shinnecok, e.g. (Moerman, 1986). Modern Homo sprays his dandelion with pesticides, killing many less weedy plants, and perhaps himself, slowly, and then goes to the dugstore to but a lecithin/selenium pill. The dandelion is one of the best sources of lecithin, according to my database. And all plants aparently contain selenium. The bitter compounds, mostly important phytonutrients for us, discourage herbivory and diseases of these bitter herbs, actually increasing their weediness. The meek shall inherit the earth. Where once the green trees were kissed by the sunrise There's a highrise 'tween the sunrise and the smog in your eye. All the other flow'rs got twisted by the herbicide squirt The last dandelions laughing, man's bitter dessert.

Before we go to the individual disease accounts, let me name the many important Amerindian medicinal plants that have made their way into world commerce, one , echinacea,being the biggest seller in herbal North American, and it was probably the most important Amerindian medicinal plant before the caucasian arrived.. Five others in the top ten US sellers are Amerindian herbs, cranberry (No. 10, a standby for cystitis), ginseng (No 4; for debility, stress, and some say impotence), goldenseal (No. 3, for most germ-induced diseases), saw palmetto (No.6, outselling the pharmaceuticals in Germany for BPH). Four also may be attributed to TCM, ephedra, ginkgo, ginseng, siberian ginseng The Chinese ephedra is clearly outselling the Amerinidan ephedras, which contain less ephedrine a/o pseudoephedrine. Siberian Ginseng comes to us both from China and Russia, and it grows as a weed here at the Herbal Village. Who knows whence came number 2, garlic, but it was mentioned even in the Bible, and figures in all major pharmacopoeia. Only one of the top ten is African, aloe, also mentioned in the Bible. Two other that are gaining importance in the world market are evening primrose for acne, alcoholism and PMS, and passionflower, for insomnia and stress. Strangely capsicum, with its capsaicin, clearly an Amerindian, food, spice and medicine, though it is one of the most widely advertised herbal medicines, from A to Z (Axsaine to Zostrix).

Too often we are provincial and only talk about North American herbs. But South America has produced several of the worlds most important medicines, like quinine and ipecac, and food farmaceuticals, like avocado; one of the best sources of MUFAs and the best plant source of vitamin D; brazilnut, world's best source of selenium; cacao, guarana and mate, important sources of xanthine alkaloids, like caffeine, theobromine and possibly theophylline; camu-camu, world's best source of vitamin C; capsicum, mentioned above as the unique source of capsaicin; mil-peso oil, a better source of MUFAs than olive oil; oil palm, one of the best sources of tocotrienols; papaya, unique source of papain and chymopapain; pineapple, unique source of bromelain.

GAIAN DISTRIBUTION OF PHYTOCHEMICALS

Once Gary Null asked me to discuss Amerindian medicinal plants for the following ailments. I could come up with a few fabulous, some good and more mediocre remedies, here at the Herbal Village. My herbal village concept came up many years ago after hearing David Hoffman talk about Gaia and about synergy, two very important concepts in my herbal philosophy. I talked about the Gaian distribution of important phytochemicals. There's e.g. a licorice in most pharmacopoeias, Amerindian, Ayurvedic, Chinese, European, etc. Though the species may be different, the chemical glycyrrhizin, and its medicinal attribues is common to all. Of the seven species of Hypericum I submitted to the NCI, all, including some strictly American species, contained hypericin a/o pseudohypericin, and one American species, Hypericum hypericoides contain more and showed more antiviral activity and would probably exhibit more antidepressant activity, than the more widely use Hypericum perforatum. Ramps and other wild onions share many chemicals and biological activities with the more famous garlic. The isoflavones antidipsomanic daidzein and antiangiogenic estrogenic genistein occur in most, if not all clovers, not just Chinese kudzu and Chinese soybean. I much prefer American black beans, butter beans and pinto beans to soybeans anyhow. They come out a little lower than some soy varieties, but I eat ten times as many, thereby getting more genistein from palatable amerindian beans than from oriental soybeans.

Analyses being published any day now by Peter Kaufmann, John Boik and myself, rank some 80 legumes as to genistein content. Psoralea, Indians black dotted bean was first at 2,150 pps, followed by kuzdu root at a distant 315 ppms., then came fermented soybean ( I suspect that other beans that are fermented will have more genistein (one USDA study showed that fungal invasion increases genistein content 100-fold), then Baptisia at 350, Japanese pagoda tree at180,, upine at 100, hog peanut at 85, with one soy at 70, anotehr at 40, tied with the more palatable tepary bean from out west. You mentioned alcoholism, and kudzu's daidzein is indicated for that. The faba-bean was by far our highest source of that. But as for total daidzein + genistein, it was Psoralea, 2250 ppms, kudzu root at 1265. Faba bean at 1,125 (and you can but a pound of them in a can for $1.25 getting significant quantities of l-dopa in the process, which also might be useful in alcoholism), then fermented miso at 755, the Baptisia at 395, clover at 185, pagoda tree at 180 (also our best source of rutin, along with buckwheat and Native American polygonums), lupine at 125, hospeanuit at 115, vegetable soybean at 105, oreintal varieties of soybean and tepary bean at 75.

On every continent, some nettle, with its urticating acetylcholine a/o choline a/o formic acid a/o histamine a/o serotonin, has been used in primitive pharmacopoeia in self flagellation for arthritis and rheumatism. Most continents have endemic sources of the antiseptic alkaloid berberine, goldenseal and coptis in America, oregon grape in western America, yellow root in Appalachia, coptis et al in China, and members of the citrus family in Asia and Africa. The pycnogenols are in the American grapes as well as the normal source, European grapes. American and Chinese ginesngs share many of the same ginsenosides, folklore and hype. GLA not only occurs in our American evening primrose but also in borage, currants and cannabis. Taxol has been found in every species of yew yet examined. And senna-like cassias on every warm continent contain the synergistic sennosides. The lignans, peltatin and podophyllotoxin, are nort restricted to the American and Ayurvedic mayaplle, but rather occur in many unrelated species, some widely distributed, some narrowly endemic, bush mints (hyptis), chervil, flax, junipers, e.g. Sitosterol from the saw palmetto has been praised for its antiprostatic activity, but sitosterol occurs in every continent, perhaps in every plant, along with campesterol, cholesterol and stigmasterol.The resveratrol is not restricted to the American, or the Chinese, or the European grapes, but probably occurs in many, if not all, astringent fruits.

And don't tell me that plant X will cure disease Y because it contains ascorbic acid, beta-carotene, glutathione, selenium, tocopherol. Probably all green leaves of all plant species contain these and thousands of other phytocehmicals, many common to all living plants, somewhat fewer common to all life, and many rather but not totally ubiquitous in green plants, and perhaps fewer unique to that individual species. Our 100,000 genes, directing the thousands of homeostatic equilibrating chemical reactions between thousand of biochemicals and zoochemicals in our bodies, have been coevolving with perhaps as many biochemicals and phytochemicals, within the many culinary, food, and medicinal plants, some still extant, that our ancestors have ingested for millions of years. We ignore this empirical wisdom derived from this coevolution at our own risk. The empirical truths of the hundreds of existing forest-dwelling ethnic groups are dieing with the wise old elders, just as the forest-dwelling species and their medicines for todays and tomorrows diseases, wil disappear. Our centennial synthetic pharmaceuticals, while sometimes quicker in action, are much more liable to upset our chemical equilibria, than are the millennial natural foods and medicines with which our ancestors. coevolved. Though our own black walnut, resembling the brain, is the best source of that brainfood serotonin, most walnuts hickories and pecans also contain high levels of serotonin. Natural salicylates probably occur in all willows, poplars, meadowsweets, and at lower levels in all plants. Rosmarinic acid, the famous antioxidant, is not restricted to rosemary. It occurs in most mints, including American bugle and self-heal, and many borage and verbena relatives.

MEDICAL PROBLEMS AND AMERINDIAN SOLUTIONS

(Parenthetical more folkloric, or not yet proven)

Acne: Echinacea, Evening Primrose, Pineapple (AHA, proteolysis), (Goldenseal, Selfheal, Yarrow)

Alcoholism: Echinacea, Evening Primrose, (Hops)

Allergies: Nettles, Wild Onion

Alzheimer's: Horse Balm (Hound's Tongue)

Amenorrhea: Bugle, Mountain Mint, Pennyroyal, Spice Bush, Sweet Flag

Anemia: Grapes, Nettles Hematinic

Angina: Angelade, Hawthorns, Ramps, Wild Onions (Arbor Vitae)

Anxiety: Passionflower (Damiana, Hops, Hypericum)

Arrhythmia: Angelade, Hawthorns, Quinine

Arthritis: Cat's Claw, Cayenne, Chaparral, Cohosh, Dragon's Blood, EPO, Licorice, Meadowsweet, Nettle, Pineapple/Papaya, Willow, Wild Yam, Yucca

Atherosclerosis: Blueberry, Brazilnut, Hawthorn, Willow

Athlete's Foot: compounds in teatree (>30% terpinen-4-ol; <15% cineole)

Att.Def. Disorder: Evening Primrose, (kava polynesian; valerian a weed in Maine)

Boils: 50 herbs indexed

Bronchitis: Capsaicin and other hots, Echinacea, Garlic, Goldenseal, Osha burdock, goldenseal, ramps

Burns: Hypericum in EPO

Bursitis: Nettle, Papaya/Pineapple and CICs

Cancer: Mayapple, Yew, Pau D'arco, Cat's claw, Walnut

Preventives: Bugle, Burdock, Echinacea, Garlic, Selfheal

Candidiasis: Echinacea, Goldenseal, Wild Garlic

Cataracts: Bugle (rosmarinic-acid)

Colds & Flu: Cayenne, Dragon's Blood, Echinacea, Goldenseal, Slippery Elm; Walnut, Wild Onion, Willow

Constipation: Paleolithic Diet and then Cascara Sagrada, Senna

Cystitis: Bearberry, Cranberry

Depressions: Hypericum (Damiana)

Diabetes: Burdock, Legumes and the Desert Indians

Diarrhea: Bilberry and Blueberry

Diverticulitis: Paleotlith Diet

Dysmenorrhea: Cohosh, Evening Primnrose

Ear Infections: Mullein and Goldenseal

Eczema: Evening Primrose

Flatulence: Any old mint, American or otherwise

Headaches: Angel's Trumpet, Walnut, Willow, Wintergreen

Hepatitis: American thistles and dandelions

Hypertension: wild garlics

Hypoglycemia:

Insects: Dittany, Horsebalm, Mountain Mint, Pennyroyal, Walnut

Menstrual Pain: American angelicas, EPO

Parasites: Barberry, Goldenseal, Ipecac, Quinine, Senna, Walnut

Pregnancy: Pennyroyal most mints

PMS: Cohosh, Evening Primrose

Prostate Conditions: Prosnut Butter:Saw Palmetto (all plants contain sitosterol), Pumpkin, Brazilnut, Licorice

Psoriasis: Barberry, Dragon's Blood,Goldenseal, Sarsaparilla

Ulcers: Licorice , Cayenne, Pumpkin (plus bactericides)

UTIs: Barberry, Bearberry, Burdock, Cranberry, Goldenseal, Wild Garlics.

Whiplash:



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